A report this week indicated Chargers running back JK Dobbins set to miss time with a knee sprain and will be at least a four-game absence from the lineup.
The Chargers announced Saturday that Dobbins has been placed on injured reserve. Safety Alohi Gilman, who has a hamstring injury, was also moved to that list.
Dobbins is coming off a strong season after three injury-plagued years with the Ravens. He has 158 carries for 766 yards and eight touchdowns, but the Chargers will have to make do with Gus Edwards, Hassan Haskins and Kimani Vidal for now.
The Chargers filled one of the open roster spots by signing veteran safety Tony Jefferson to the active roster. They also called up cornerback Dicaprio Bootle and linebacker Jeremiah Jean-Baptiste from the practice squad on an interim basis.